Folate Metabolic Pathway and Susceptibility to Childhood Acute Lymphoblastic Leukaemia in North Portugal. The role of C677T and A1298C MTHFR Polymorphisms
نویسندگان
چکیده
1 IPATIMUP, Rua Dr. Roberto Frias s/n 4200 Porto, Portugal;Tel: +351225570700; Fax: +351225570799 2 Escola Superior de Saúde Jean Piaget/Nordeste, Macedo de Cavaleiros, Portugal 3 Serviço de Hematologia Clínica, Hospital Geral S. João, Porto, Portugal 4 Instituto Português de Oncologia, Porto, Portugal 5 Faculdade de Ciências da Universidade do Porto, Porto, Portugal 6 Instituto de Genética Médica Jacinto Magalhães, Porto, Portugal
منابع مشابه
Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia.
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation. Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the MTHFR gene could modify the susceptibility to cancer. Recently, the C677T and A1298C mutations of MTHFR were discovered to be associated with susceptib...
متن کاملAssociation of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population
BACKGROUND The aim of this study was to investigate the relationship between the polymorphisms of the methylenetetrahytrofolate reductase (MTHFR) gene and susceptibility to childhood acute lymphoblastic leukemia (ALL). METHODS A case-control study was conducted among 98 children with ALL and 93 age- and sex- matched non-ALL controls. Genotyping of MTHFR C677T and A1298C polymorphisms was perf...
متن کاملRole of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance. Here, we provide additional evidence on the protective role of these polymorphisms in acute lymphoblastic leukemia (ALL), the most common pediatric c...
متن کاملAssociation of Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T and A1298C Polymorphisms with Myocardial Infarction From North of Fars Province
Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies. The aim of this study was to investigate whether genetic polymorphisms of MTHFR (C677T, A1298C) contributed to the development of myocardial infarction (MI). Materials and Methods: The present case-contro...
متن کاملMethylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population.
BACKGROUND AND OBJECTIVES Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and DNA methylation and synthesis. Some genotypes of this highly polymorphic enzyme are associated with decreased activity. Previous studies have suggested that individuals with the MTHFR 677TT, 1298AC and 1298CC have a lower risk of adult acute lymphoblastic leukemia (ALL)....
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